Exploring Immunometabolism Research
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NYCU Hsu Lab
Dive into cutting-edge research at NYMU IMI Hsu Immunometabolism Lab. Our work has been featured in prestigious scientific journals such as Cell Reports, EMBO Reports, and eLife. We are dedicated to unraveling the intricate connections between the immune system and metabolism to advance human health. Join us in our mission to discover novel therapeutic strategies and insights into immunometabolism. Explore our ongoing projects, publications, and collaborations that are shaping the future of this exciting field.
Published Work
The Fruits of Our Efforts
2024
Equilibrative nucleoside transporter 3 supports microglial functions and protects against the progression of Huntington’s disease in the mouse model.
Ying-Sui Lu, Wei-Chien Hung, Yu-Ting Hsieh, Pei-Yuan Tsai, Tsai-Hsien Tsai, Hsiu-Han Fan, Ya-Gin Chang, Hui-Kuei Cheng, Shen-Yan Huang, Hsin-Chuan Lin, Yan-Hua Lee, Tzu-Hsiang Shen, Bing-Yu Hung, Jin-Wu Tsai, Ivan Dzhagalov, Irene Han-Juo Cheng, Chun-Jung Lin, Yijuang Chern, Chia-Lin Hsu*
Brain, Behavior, and Immunity. 2024 Volume 120, August 2024,413-429
2023
IFN-stimulated metabolite transporter ENT3 facilitates viral genome release.
Hsieh, Y.-T., Tsai, T.-L., Huang, S.-Y., Heng, J.-W., Huang, Y.-C., Tsai, P.-Y., Tu, C.-C., Chao, T.-L., Tsai, Y.-M., Chang, P.-C., Lee, C.-K., Yu, G.-Y., Chang, S.-Y., Dzhagalov, I.L. and Hsu, C.-L.*
EMBO rep e55286.
2023
Deletion of equilibrative nucleoside transporter 2 disturbs energy metabolism and exacerbates disease progression in an experimental model of Huntington's disease.
Ching-Ya Chen, Fang-Yi Chou, Ya-Gin Chang, Chin-Jui Ho, Kuo-Chen Wu, Chia-Lin Hsu, Yijuang Chern, Chun-Jung Lin.
Neurobiology of Disease. 177 (2023) 106004.
https://doi.org/10.1016/j.nbd.2023.106004
2023
Protocol for standardized intrathymic injection in mice.
Tsung-Lin Tsai, Pei-Yuan Tsai, Ivan L.Dzhagalov, Chia-Lin Hsu*
STAR protocols. 2023 Jan
2022
Thymic macrophages consist of two populations with distinct localization and origin.
Tyng-An Zhou, Hsuan-Po Hsu, Yueh-Hua Tu, Hui-Kuei Cheng, Chih-Yu Lin, Nien-Jung Chen, Jin-Wu Tsai, Ellen A Robey, Hsuan-Cheng Huang, Chia-Lin Hsu, Ivan L Dzhagalov.
​eLife 2022;11:e75148
2022
Heparin is required for the formation of granules in connective tissue mast cells
Sandra Abril Herrera-Heredia, Hsuan-Po Hsu, Cheng-Yen Kao, Yu-Huan Tsai, Yu Yamaguchi, Axel Roers, Chia-Lin Hsu and Ivan L. Dzhagalov
Frontiers in Immunology, Nov 9, 2022
2022
Multiomics reveal the central role of pentose phosphate pathway in resident thymic macrophages to cope with efferocytosis-associated stress.
Tsung-Lin Tsai, Tyng-An Zhou, Yu-Ting Hsieh, Ju-Chu Wang, Hui-Kuei Cheng, Chen-Hua Huang, Pei-Yuan Tsai, Hsiu-Han Fan, Hsing-Kai Feng, Yu-Chia Huang, Chen-Ching Lin, Chao-Hsiung Lin, Chih-Yu Lin, Ivan L. Dzhagalov, Chia-Lin Hsu*
Cell reports, Vol. 40, ISSUE 2, 111065, JULY 12, 2022
2021
Evaluation of Mitochondria Content and Function in Live Cells by Multi-color Flow Cytometric Analysis.
Fan HH, Tsai TL, Dzhagalov I, Hsu CL*
Methods in Molecular Biology, 2021, Vol. 2276:
203-213. doi: 0.1007/978-1-0716-1266-8_15
2021
Heparan sulfate is essential for thymus growth
Hsuan-Po Hsu, Yun-Tzu Chen, Yu-Ying Chen, Chih-Yu Lin, Po-Yu Chen, Shio-Yi Liao, Ciara Christianne Y. Lim, Yu Yamaguchi, Chia-Lin Hsu, Ivan L. Dzhagalov
Journal of Biological Chemistry, Feb, 2021, S0021-9258(21)00192-7,
https://doi.org/10.1016/j.jbc.2021.100419
2020
Examination of Fas-induced apoptosis of murine thymocytes in thymic tissue slices reveals that Fas is dispensable for negative selection
Feng HK, CF Chu, Sun KH, Hsu CL, Dzhagalov I.
Front. Cell Dev. Biol., 21 October 2020 | https://doi.org/10.3389/fcell.2020.586807
2020
Upregulation of RelB in the miR-122 knockout mice contributes to increased levels of proinflammatory chemokines/cytokines in the liver and macrophages
Hsu KH, Wei CW, Su YR, Chou T, Lin YL, Yang FC, Tsou AP, Hsu CL, Tseng PH, Chen NJ, Jeng KS, Leu CM.
Immunology Letters, July 02, 2020
2020
Testing the Efficiency and Kinetics of Negative Selection Using Thymic Slices
Zhou TA, Hsu CL, Dzhagalov IL*
​Methods Mol Biol. 2020;2111:205-219. doi: 10.1007/978-1-0716-0266-9_17.
2018
Identification of Lysosomal and Extralysosomal Globotriaosylceramide (Gb3) Accumulations Before the Occurrence of Typical Pathological Changes in the Endomyocardial Biopsies of Fabry Disease Patients.
Hsu MJ, Chang FP,Lu YH,Hung SC,Wang YC, Yang AH, Lee HR, Sung SH, Wang YF, Yu WC, Hsu TR,Huang, Chang SK, Dzhagalov I, Hsu CL*, Niu DM*.
Genetics in Medicine 06 June 2018: 21, 224-232
doi:10.1038/s41436-018-0010-z
2016
Later Onset Fabry Disease, Cardiac Damage Progress in Silence
Hsu TR, Hung SC, Chang FP, Yu WC, Sung SH, Hsu CL, Dzhagalov I, Yang CF, Chu TH, Lee
HJ, Lu YH, Chang SK, Liao HC, Lin HY, Liao TC, Lee PC, Li HY, Yang AH, Ho HC, Chiang CC,
Lin CY, Desnick RJ, Niu DM.
Journal of the American College of Cardiology 68, 2016: 2554-2563.
2012
Equilibrative Nucleoside Transporter 3 Deficiency Perturbs Macrophage Lysosome Functions and Homeostasis.
Hsu CL, Lin W, Seshasayee D, Chen YH, Ding X, Lin Z, Suto E, Huang Z, Lee WP, Park H, Xu M, Sun M, Rangell L, Lutman JL, Ulufatu S, Stefanich E, Chalouni C, Sagolla M, Diehl L, Fielder P, Dean B, Balazs M and Martin F.
Science, 6 January 2012: 89-92.